Depilus Cream Eflornithine Hydrochloride 13.9% 15gDepilus Cream Eflornithine Hydrochloride 13. 9% 15g Prescription required. Depilus Cream by Atco Pharma contains Eflornithine Hydrochloride 13. 9% a prescription only topical treatment that slows the regrowth of unwanted facial hair in women. It inhibits ornithine decarboxylase, an enzyme essential for hair follicle cell proliferation, resulting in finer, slower growing facial hair over time. Active Ingredient Eflornithine Hydrochloride 13. 9%: