PentraCream™ Anhydrous Hybrid Transdermal Cream BasePentraCream Anhydrous is an elegant, brilliant white transdermal cream base that quickly vanishes upon application. This unique proprietary base offers several advantages over traditional oil water topicals, which tend to separate or have low API carrying capacity. Specifically designed for hormone replacement or pain management in both men and women, PentraCream Anhydrous features a high API carrying matrix, allowing for low volume administration.